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Cell Metab. 2012 Oct 3;16(4):414-9. doi: 10.1016/j.cmet.2012.09.002. Epub 2012 Sep 20.

Expanding roles for SREBP in metabolism.

Author information

1
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

Abstract

Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis. Recent studies reveal expanding roles for SREBPs with the description of new regulatory mechanisms, the identification of unexpected transcriptional targets, and the discovery of functions for SREBPs in type II diabetes, cancer, immunity, neuroprotection, and autophagy.

PMID:
23000402
PMCID:
PMC3466394
DOI:
10.1016/j.cmet.2012.09.002
[Indexed for MEDLINE]
Free PMC Article

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