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Trends Immunol. 2012 Dec;33(12):607-12. doi: 10.1016/j.it.2012.08.007. Epub 2012 Sep 20.

Immunity's fourth dimension: approaching the circadian-immune connection.

Author information

1
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Abstract

The circadian system ensures the generation and maintenance of self-sustained ~24-h rhythms in physiology that are linked to internal and environmental changes. In mammals, daily variations in light intensity and other cues are integrated by a hypothalamic master clock that conveys circadian information to peripheral molecular clocks that orchestrate physiology. Multiple immune parameters also vary throughout the day and disruption of circadian homeostasis is associated with immune-related disease. Here, we discuss the molecular links between the circadian and immune systems and examine their outputs and disease implications. Understanding the mechanisms that underlie circadian-immune crosstalk may prove valuable for devising novel prophylactic and therapeutic interventions.

PMID:
23000010
PMCID:
PMC3712756
DOI:
10.1016/j.it.2012.08.007
[Indexed for MEDLINE]
Free PMC Article
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