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Clin Lymphoma Myeloma Leuk. 2012 Dec;12(6):400-5. doi: 10.1016/j.clml.2012.06.006. Epub 2012 Sep 19.

Autoimmune manifestations in large granular lymphocyte leukemia.

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Department of Medicine, University of Connecticut Medical Center, Farmington, CT 06030-1235, USA.


Large granular lymphocyte (LGL) leukemia features a group of indolent lymphoproliferative diseases that display a strong association with various autoimmune conditions. Notwithstanding, these autoimmune conditions have not been comprehensively characterized or systematized to date. As a result, their clinical implications remain largely unknown. The authors offer a comprehensive review of the existing literature on various autoimmune conditions documented in the course of T-cell LGL (T-LGL) leukemia. Though some of them are thought be secondary to the LGL leukemia, others could be primary and might even play a role in its pathogenesis. A considerable clinico-laboratory overlap between T-LGL leukemia associated with rheumatoid arthritis and Felty's syndrome suggests that they are just different eponyms for the same clinical entity.

[Indexed for MEDLINE]

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