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Chem Biol. 2012 Sep 21;19(9):1082-3. doi: 10.1016/j.chembiol.2012.08.016.

The secret of MIM: a novel, MCL-1-specific small molecule.

Abstract

Reactivating apoptosis is a major goal of cancer research, and MCL-1 has emerged as a primary pharmacological target. A screen for small molecules that could compete with stabilized helical peptides for MCL-1 binding yielded small molecule MIM1 (see the article by Cohen et al. in this issue of Chemistry & Biology). MIM1 selectively targets MCL-1, and can kill MCL-1-dependent leukemia cells.

PMID:
22999875
DOI:
10.1016/j.chembiol.2012.08.016
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