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Heart Fail Clin. 2012 Oct;8(4):633-41. doi: 10.1016/j.hfc.2012.06.003. Epub 2012 Aug 10.

Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure.

Author information

1
Department of Life Science, Gachon University, Bokjung-dong, Sujung-gu, Seongnam, Gyunggi-do, South Korea.

Abstract

In the setting of obesity and type 2 diabetes mellitus, the ectopic disposition of lipids may be a cause of heart failure. Clinical studies have clearly shown a correlation between the accumulation of triglycerides and heart dysfunction. In this process, it is likely that there are also changes in the contents of sphingolipids. Sphingolipids are important structural and signaling molecules. One specific sphingolipid, ceramide, may cause cardiac dysfunction, whereas another, sphingosine 1-phosphate, is cardioprotective. In this review, the authors focus on the role of sphingolipids in the development and prevention of cardiac failure.

PMID:
22999245
PMCID:
PMC4548923
DOI:
10.1016/j.hfc.2012.06.003
[Indexed for MEDLINE]
Free PMC Article

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