Format

Send to

Choose Destination
See comment in PubMed Commons below
Heart Fail Clin. 2012 Oct;8(4):609-17. doi: 10.1016/j.hfc.2012.06.005. Epub 2012 Aug 9.

Insulin resistance and heart failure: molecular mechanisms.

Author information

1
Department of Internal Medicine, University of Missouri School of Medicine, One Hospital Drive, Columbia, MO 65212, USA.

Abstract

This article addresses the issue of insulin resistance and associated reductions in cardiac insulin metabolic signaling, which is emerging as a major factor in the development of heart failure, and assumes more importance because of an epidemic increase in obesity and the cardiorenal metabolic syndrome in our aging population. The effects of cardiac insulin resistance are exacerbated by metabolic, endocrine, and cytokine alterations associated with systemic insulin resistance. Understanding the molecular mechanisms linking insulin resistance and heart failure may help to design new and more effective mechanism-based drugs to improve myocardial and systemic insulin resistance.

PMID:
22999243
PMCID:
PMC3457065
DOI:
10.1016/j.hfc.2012.06.005
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center