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Seizure. 2013 Jul;22(6):424-32. doi: 10.1016/j.seizure.2012.08.011. Epub 2012 Sep 19.

Computerized cognitive testing in epilepsy (CCTE): a new method for cognitive screening.

Author information

1
Epilepsy Center, Department of Neurology, University of Erlangen-Nürnberg, Germany. katrin.kurzbuch@uk-erlangen.de

Abstract

PURPOSE:

Optimized therapy in epilepsy should include individual care for cognitive functions. Here we introduce a computerized screening instrument, called "Computerized Cognitive Testing in Epilepsy" (CCTE), which allows for time-efficient repetitive assessment of the patient's cognitive profile regarding the domains of memory and attention, which are frequently impaired due to side effects of antiepileptic medication.

METHODS:

The CCTE battery takes 30min and covers tasks of verbal and figural memory, cognitive speed, attention and working memory. The patient's results are displayed immediately in comparison to age-related normative data. For evaluation of psychometrics and clinical correlations, data from patients of a tertiary referral epilepsy center (n=240) and healthy subjects (n=83) were explored.

RESULTS:

CCTE subtests show good reliability and concurrent validity compared to standard neuropsychological tests (p<0.01). Adverse cognitive effects of antiepileptic medication can be detected (p<0.05), e.g. significant negative effects of increasing drug load. Specific epilepsy subgroups, e.g. focal versus primary generalized epilepsy or right versus left mesial temporal lobe epilepsy, showed different CCTE profiles.

CONCLUSION:

CCTE appears valuable for early detection of individual cognitive alterations related to medication. In addition, it displays interesting differences between epilepsy syndromes. The CCTE battery provides a standardized, time- and personnel-efficient assessment of cognitive functions open to a large number of patients and applicable for clinical and scientific use in epilepsy.

PMID:
22999215
DOI:
10.1016/j.seizure.2012.08.011
[Indexed for MEDLINE]
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