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Neuron. 2012 Sep 20;75(6):935-8. doi: 10.1016/j.neuron.2012.09.006.

Neurodegeneration: new road leads back to the synapse.

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1
Department of Clinical Genetics, Center for Neurogenomics and Cognitive Research-CNCR, Neuroscience Campus Amsterdam-NCA, VU Medical Center, 1081 HV Amsterdam, The Netherlands.

Abstract

Much of Parkinson's research over the last decade has focused on cellular stress as a candidate mechanism. In this issue of Neuron, a new study by Matta et al. (2012) addressing the biological functions of the Parkinson's gene LRRK2 now identifies a presynaptic substrate, homing in on the idea that synapse loss might be a central early aspect of neurodegeneration.

PMID:
22998859
DOI:
10.1016/j.neuron.2012.09.006
[Indexed for MEDLINE]
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