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Pediatr Blood Cancer. 2013 Feb;60(2):332-5. doi: 10.1002/pbc.24311. Epub 2012 Sep 19.

Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression.

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Department of Neuro-Oncology, Dana Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA.


Surgery alone is curative for most children with localized MYCN-non-amplified neuroblastoma. However, 10-15% will develop recurrent loco-regional disease, and very rarely, patients will relapse metastatically. Currently, it is not possible to predict which child with localized, MYCN-non-amplified neuroblastoma will develop disseminated disease. We report two children who presented with favorable biology, localized neuroblastoma and subsequently relapsed with metastatic disease after treatment with surgery. Whole-genome DNA copy number analyses performed on the diagnostic tumors identified 15 (case 1) and 8 (case 2) segmental chromosomal alterations. Further analysis of the prognostic value of whole-genome analysis in children with localized neuroblastoma is warranted.

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