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Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10556-60. doi: 10.1002/anie.201204663. Epub 2012 Sep 20.

Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles.

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1
Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València-Universitat de València. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Camino de Vera s/n, 46022 Valencia (Spain).

Abstract

Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.

PMID:
22996839
DOI:
10.1002/anie.201204663
[Indexed for MEDLINE]
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