Abstract
Non-Hodgkin's lymphoma (NHL) affecting the ethmoid sinus and epiglottis is uncommon. Furthermore, synchronous NHLs involving the ethmoid sinus and epiglottis are extremely rare and have not been reported previously. This article reports synchronous, primary, diffuse, large B-cell lymphoma (DLBCL) arising in the ethmoid sinus and epiglottis, which was successfully treated by immunochemotherapy. A careful examination of the head and neck is necessary to determine the existence of multiple synchronous primary tumors, because primary synchronous occurrence of DLBCL in the head and neck is unusual and can impact the prognosis adversely.
Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
MeSH terms
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Adult
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Antibodies, Monoclonal, Murine-Derived / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Epiglottis*
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Ethmoid Sinus*
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Humans
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Immunologic Factors / therapeutic use*
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Laryngeal Neoplasms / drug therapy*
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Laryngeal Neoplasms / pathology
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Lymphoma, Large B-Cell, Diffuse / drug therapy*
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Lymphoma, Large B-Cell, Diffuse / pathology
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Male
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Neoplasms, Multiple Primary / drug therapy*
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Neoplasms, Multiple Primary / pathology
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Paranasal Sinus Neoplasms / drug therapy*
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Paranasal Sinus Neoplasms / pathology
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Paranasal Sinus Neoplasms / therapy*
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Prednisone / administration & dosage
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Rituximab
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Tomography, X-Ray Computed
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Vincristine / administration & dosage
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Vision Disorders / etiology
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Visual Acuity
Substances
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Antibodies, Monoclonal, Murine-Derived
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Immunologic Factors
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R-CHOP protocol
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone