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Nat Rev Cancer. 2012 Oct;12(10):671-84. doi: 10.1038/nrc3322. Epub 2012 Sep 21.

Paths to stemness: building the ultimate antitumour T cell.

Author information

1
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. gattinol@mail.nih.gov

Abstract

Stem cells are defined by the ability to self-renew and to generate differentiated progeny, qualities that are maintained by evolutionarily conserved pathways that can lead to cancer when deregulated. There is now evidence that these stem cell-like attributes and signalling pathways are also shared among subsets of mature memory T lymphocytes. We discuss how using stem cell-like T cells can overcome the limitations of current adoptive T cell therapies, including inefficient T cell engraftment, persistence and ability to mediate prolonged immune attack. Conferring stemness to antitumour T cells might unleash the full potential of cellular therapies.

PMID:
22996603
DOI:
10.1038/nrc3322
[Indexed for MEDLINE]

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