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Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10664-9. doi: 10.1002/anie.201202438. Epub 2012 Sep 20.

Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.

Author information

1
Fakultät für Chemie, Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany.

Abstract

Not in the public domain: Site-directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in bacteria. Redox derivatizations are used to change the bioactivity profile of the compounds.

PMID:
22996590
DOI:
10.1002/anie.201202438
[Indexed for MEDLINE]

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