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Int J Oral Sci. 2012 Sep;4(3):135-40. doi: 10.1038/ijos.2012.54. Epub 2012 Sep 21.

Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries.

Author information

1
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.

Abstract

Alkali production by oral bacteria is believed to have a major impact on oral microbial ecology and to be inhibitory to the initiation and progression of dental caries. A substantial body of evidence is beginning to accumulate that indicates the modulation of the alkalinogenic potential of dental biofilms may be a promising strategy for caries control. This brief review highlights recent progress toward understanding molecular genetic and physiologic aspects of important alkali-generating pathways in oral bacteria, and the role of alkali production in the ecology of dental biofilms in health and disease.

PMID:
22996271
PMCID:
PMC3465751
DOI:
10.1038/ijos.2012.54
[Indexed for MEDLINE]
Free PMC Article

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