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Chem Commun (Camb). 2012 Nov 4;48(85):10511-3.

Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process.

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1
Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.

Abstract

The non-enzymatic kinetic resolution of diversely substituted primary propargylic amines is reported featuring a highly selective acetyl transfer using (1S,2S)- in conjunction with Aliquat(TM) 336, affording the corresponding enantio-enriched N-acetylated propargylic amines with unprecedented levels of selectivity (s-factors of up to 193 at 50% conversion).

PMID:
22996071
DOI:
10.1039/c2cc35719d
[Indexed for MEDLINE]
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