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Bioorg Med Chem Lett. 2012 Oct 15;22(20):6358-61. doi: 10.1016/j.bmcl.2012.08.077. Epub 2012 Aug 27.

A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent simulant.

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1
Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

Abstract

N-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromo-fluorogenic sensor for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecular deoxylactam. The successful detection of diethyl chlorophosphate suggests the utility of rhodamine-deoxylactams as the chromo-fluorogenic signal reporting platform for design of sensors targeting reactive chemical species via various chemistries.

PMID:
22995618
DOI:
10.1016/j.bmcl.2012.08.077
[Indexed for MEDLINE]
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