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Mol Ecol Resour. 2012 Nov;12(6):1145-50. doi: 10.1111/1755-0998.12017. Epub 2012 Sep 21.

Consistent divergence times and allele sharing measured from cross-species application of SNP chips developed for three domestic species.

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Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.


Recent advances in technology facilitated development of large sets of genetic markers for many taxa, though most often model or domestic organisms. Cross-species application of genomic technologies may allow for rapid marker discovery in wild relatives of taxa with well-developed resources. We investigated returns from cross-species application of three commercially available SNP chips (the OvineSNP50, BovineSNP50 and EquineSNP50 BeadChips) as a function of divergence time between the domestic source species and wild target species. Across all three chips, we observed a consistent linear decrease in call rate (~1.5% per million years), while retention of polymorphisms showed an exponential decay. These results will allow researchers to predict the expected amplification rate and polymorphism of cross-species application for their taxa of interest, as well as provide a resource for estimating divergence times.

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