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BMC Nephrol. 2012 Sep 20;13:115. doi: 10.1186/1471-2369-13-115.

Cardiovascular determinants of prognosis in normotensive hemodialysis patients.

Author information

1
Department of Medicine, Taipei, Taiwan.

Abstract

BACKGROUND:

Normotension has been hold to be the goal of hemodialysis. It remains obscure which cardiovascular parameter determines the prognosis in these normotensive hemodialysis patients.

METHODS:

We prospectively enrolled 145 hemodialysis patients, who had attained normotension without anti-hypertensive medications, and followed them for 72.6 ± 28.5 months. Important cardiovascular parameters were obtained at enrollment. Predictors for all-cause and cardiovascular mortalities were identified with the Cox model.

RESULTS:

There were 45 (18 cardiovascular/27 non-cardiovascular) deaths occurred during follow-up. Age, diabetes, left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), carotid intima-media thickness (CIMT), and aortic pulse wave velocity (PWV) were significant predictors for all-cause and cardiovascular mortalities. After adjustment for age and diabetes, only LVEF was significantly associated with all-cause mortality. LVEF was significantly associated with cardiovascular mortality. LVEF remained as a significant independent predictor of cardiovascular death after adjusting for age, diabetes, LVMI, CIMT, or PWV, respectively.

CONCLUSION:

LVEF is the independent predictor for all-cause and cardiovascular mortalities in the normotensive hemodialysis patients.

PMID:
22994452
PMCID:
PMC3504582
DOI:
10.1186/1471-2369-13-115
[Indexed for MEDLINE]
Free PMC Article

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