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Transplantation. 2012 Oct 27;94(8):784-93. doi: 10.1097/TP.0b013e318269e64f.

The Seville expert workshop for progress in posttransplant lymphoproliferative disorders.

Author information

  • 1Nephrology and Transplantation Service, Hôpital Saint-Louis, Paris, France. denis.glotz@sls.aphp.fr

Abstract

: Posttransplant lymphoproliferative disorders (PTLDs) are associated with significant morbidity and mortality among solid-organ transplant patients, but approaches to diagnosis and management vary considerably. An international multidisciplinary panel evaluated current understanding of risk factors and classification systems and developed recommendations to aid in PTLD prevention. We considered evidence on PTLD risk factors including Epstein-Barr virus serostatus and immunosuppression and identified knowledge gaps for future research. Recommendations address prophylactic and preemptive strategies to minimize PTLD development, including modulation of immunosuppression and antiviral drug regimens. Finally, new classification criteria were outlined that may help facilitate standardized reporting and improve our understanding of PTLD.

PMID:
22992767
DOI:
10.1097/TP.0b013e318269e64f
[PubMed - indexed for MEDLINE]
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