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Oncol Rep. 2012 Dec;28(6):1945-52. doi: 10.3892/or.2012.2036. Epub 2012 Sep 17.

hTERT-based therapy: a universal anticancer approach (Review).

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Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China.


Human telomerase reverse transcriptase (hTERT) has been identified as a major protein involved in aberrant cell proliferation, immortalization, metastasis and stemness maintenance in a majority of tumors, yet it has little or no expression in normal somatic cells. During the past few years, the development of hTERT-based therapies such as immunotherapy, suicide gene therapy and small-molecule interfering therapy have become critical and specific for eradicating all types of cancer. Here, current knowledge regarding hTERT and its involvement in various cancers and its role as a target of cancer therapies are reviewed. Additionally, hurdles to new cancer therapy development and new therapeutic opportunities are described, along with areas that require further investigation.

[Indexed for MEDLINE]

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