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Nat Rev Mol Cell Biol. 2012 Oct;13(10):607-25. doi: 10.1038/nrm3440. Epub 2012 Sep 20.

Endoplasmic reticulum-mitochondria contacts: function of the junction.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309, USA.

Abstract

The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER-mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER-mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca(2+) signalling and the control of mitochondrial biogenesis and intracellular trafficking.

PMID:
22992592
PMCID:
PMC5111635
DOI:
10.1038/nrm3440
[Indexed for MEDLINE]
Free PMC Article

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