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Appl Phys Lett. 2012 Aug 20;101(8):81108. Epub 2012 Aug 22.

Digital optical phase conjugation of fluorescence in turbid tissue.

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Department of Electrical Engineering, California Institute of Technology, Pasadena, California, USA.


We demonstrate a method for phase conjugating fluorescence. Our method, called reference free digital optical phase conjugation, can conjugate extremely weak, incoherent optical signals. It was used to phase conjugate fluorescent light originating from a bead covered with 0.5 mm of light-scattering tissue. The phase conjugated beam refocuses onto the bead and causes a local increase of over two orders of magnitude in the light intensity. Potential applications are in imaging, optical trapping, and targeted photochemical activation inside turbid tissue.

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