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Wiley Interdiscip Rev RNA. 2012 Nov-Dec;3(6):759-78. doi: 10.1002/wrna.1134. Epub 2012 Sep 18.

Computational analysis of noncoding RNAs.

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1
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. wash@mit.edu

Abstract

Noncoding RNAs have emerged as important key players in the cell. Understanding their surprisingly diverse range of functions is challenging for experimental and computational biology. Here, we review computational methods to analyze noncoding RNAs. The topics covered include basic and advanced techniques to predict RNA structures, annotation of noncoding RNAs in genomic data, mining RNA-seq data for novel transcripts and prediction of transcript structures, computational aspects of microRNAs, and database resources.

PMID:
22991327
PMCID:
PMC3472101
DOI:
10.1002/wrna.1134
[Indexed for MEDLINE]
Free PMC Article
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