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  • PMID: 22990704 was deleted because it is a duplicate of PMID: 23402028
Adv Exp Med Biol. 2013;735:197-206.

Complement-targeted therapeutics in periodontitis.

Author information

1
Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. geoh@upenn.edu

Abstract

Periodontitis is a prevalent oral chronic inflammatory disease which, in severe forms, may exert a major impact on systemic health. Clinical and histological observations, as well as experimental animal studies, suggest involvement of the complement system in periodontitis. However, the precise roles of the various complement components and pathways in periodontitis have only recently started to be elucidated. In this chapter, we review recent progress in the field and discuss the potential of complement-targeted therapeutics in the treatment of periodontitis.

PMID:
23402028
PMCID:
PMC3466049
DOI:
10.1007/978-1-4614-4118-2_13
[Indexed for MEDLINE]

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