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Plant Signal Behav. 2012 Nov;7(11):1434-7. doi: 10.4161/psb.21960. Epub 2012 Sep 18.

The salicylic acid dependent and independent effects of NMD in plants.

Author information

1
Centre for Plant Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Abstract

In eukaryotes, nonsense-mediated mRNA decay (NMD) targets aberrant and selected non-aberrant mRNAs for destruction. A recent screen for mRNAs showing increased abundance in Arabidopsis NMD-deficient mutants revealed that most are associated with the salicylic acid (SA)-mediated defense pathway. mRNAs with conserved peptide upstream open reading frames (CpuORFs or CuORFs) are hugely overrepresented among the smaller class of NMD-regulated transcripts not associated with SA. Here we show that the common phenotypes observed in Arabidopsis NMD mutants are SA-dependent, whereas the upregulation of CpuORF-containing transcripts in NMD mutants is independent of SA. We speculate that CpuORFs could allow the conditional targeting of mRNAs for destruction using the NMD pathway.

KEYWORDS:

Arabidopsis; conserved upstream open reading frame; nonsense-mediated mRNA decay; salicylic acid

PMID:
22990450
PMCID:
PMC3548866
DOI:
10.4161/psb.21960
[Indexed for MEDLINE]
Free PMC Article

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