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Sci Signal. 2012 Sep 18;5(242):re5.

Pseudogenes: newly discovered players in human cancer.

Author information

1
Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori (CRL-ITT), c/o IFC-CNR Via Moruzzi 1, 56124 Pisa, Italy. laura.poliseno@gmail.com

Abstract

Because they are generally noncoding and thus considered nonfunctional and unimportant, pseudogenes have long been neglected. Recent advances have established that the DNA of a pseudogene, the RNA transcribed from a pseudogene, or the protein translated from a pseudogene can have multiple, diverse functions and that these functions can affect not only their parental genes but also unrelated genes. Therefore, pseudogenes have emerged as a previously unappreciated class of sophisticated modulators of gene expression, with a multifaceted involvement in the pathogenesis of human cancer.

PMID:
22990117
DOI:
10.1126/scisignal.2002858
[Indexed for MEDLINE]
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