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BMC Neurosci. 2012 Sep 18;13:109. doi: 10.1186/1471-2202-13-109.

Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal peroxisome proliferator activated receptors (PPARα and PPARγ) gene expression in rats.

Author information

1
Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. ymgoh@vet.upm.edu.my.

Abstract

BACKGROUND:

This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague-Dawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10 weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPARα and PPARγ genes were determined using real-time PCR.

RESULTS:

Decreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPARα and PPARγ gene expression. The animals with the lowest dietary n-6: n-3 PUFA ratio presented the highest spatial learning improvement and PPAR gene expression.

CONCLUSION:

It can be concluded that modulation of n-6: n-3 PUFA ratios in the diet may lead to increased hippocampal PPAR gene expression and consequently improved spatial learning and memory in rats.

PMID:
22989138
PMCID:
PMC3465241
DOI:
10.1186/1471-2202-13-109
[Indexed for MEDLINE]
Free PMC Article
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