Format

Send to

Choose Destination
Comput Math Methods Med. 2012;2012:153212. doi: 10.1155/2012/153212. Epub 2012 Sep 4.

Microdosimetry for targeted alpha therapy of cancer.

Author information

1
Centre for Experimental Radiation Oncology, St. George Clinical School, University of New South Wales, Kogarah, NSW 2217, Australia. cyhuangsysu@gmail.com

Abstract

Targeted alpha therapy (TAT) has the advantage of delivering therapeutic doses to individual cancer cells while reducing the dose to normal tissues. TAT applications relate to hematologic malignancies and now extend to solid tumors. Results from several clinical trials have shown efficacy with limited toxicity. However, the dosimetry for the labeled alpha particle is challenging because of the heterogeneous antigen expression among cancer cells and the nature of short-range, high-LET alpha radiation. This paper demonstrates that it is inappropriate to investigate the therapeutic efficacy of TAT by macrodosimetry. The objective of this work is to review the microdosimetry of TAT as a function of the cell geometry, source-target configuration, cell sensitivity, and biological factors. A detailed knowledge of each of these parameters is required for accurate microdosimetric calculations.

PMID:
22988479
PMCID:
PMC3439982
DOI:
10.1155/2012/153212
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Publishing Corporation Icon for PubMed Central
Loading ...
Support Center