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Front Physiol. 2012 Sep 12;3:364. doi: 10.3389/fphys.2012.00364. eCollection 2012.

Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects.

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1
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.

Abstract

BACKGROUND:

The angiotensin converting enzyme 2 (ACE2) G8790A gene polymorphism has been associated with the susceptibility to essential hypertension (EH), but the results are disputable.

OBJECTIVE AND METHODS:

To investigate the relationship between the ACE2 G8790A gene polymorphism and EH, eight separate studies with 5260 subjects were meta-analyzed. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated by a random effect model.

RESULTS:

In the ACE2 G8790A gene polymorphism and EH meta-analysis in a Chinese population, no significant association was found between the ACE2 G8790A gene polymorphism and EH (OR: 1.03, 95% CI: 0.87-1.21, P = 0.76). In the stratified analysis by gender, no significant risk was found among males (OR: 1.06, 95% CI: 0.82-1.36, P = 0.66) or females (OR: 0.98, 95% CI: 0.77-1.24, P = 0.85). Under a dominant model of inheritance in the female subgroup, the pooled OR for the GG/GA + AA value was 1.01 (95% CI: 0.82-1.25, P = 0.92). Under a recessive model of inheritance in the female subgroup, the pooled OR for the AA/AG + GG value was 0.93 (95% CI: 0.50-1.73, P = 0.83).

CONCLUSION:

The current meta-analysis suggested that the ACE2 G8790A gene polymorphism might not be related to the increased EH risk in the Chinese population.

KEYWORDS:

G8790A; angiotensin converting enzyme 2; gene polymorphism; hypertension; meta-analysis

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