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Front Aging Neurosci. 2012 Sep 12;4:15. doi: 10.3389/fnagi.2012.00015. eCollection 2012.

Characterizing cognitive aging of recognition memory and related processes in animal models and in humans.

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Evelyn F. McKnight Brain Institute, University of Arizona Tucson, AZ, USA ; Memory and Aging, ARL Division of Neural Systems, University of Arizona Tucson, AZ, USA.


Analyses of complex behaviors across the lifespan of animals can reveal the brain regions that are impacted by the normal aging process, thereby, elucidating potential therapeutic targets. Recent data from rats, monkeys, and humans converge, all indicating that recognition memory and complex visual perception are impaired in advanced age. These cognitive processes are also disrupted in animals with lesions of the perirhinal cortex, indicating that the the functional integrity of this structure is disrupted in old age. This current review summarizes these data, and highlights current methodologies for assessing perirhinal cortex-dependent behaviors across the lifespan.


medial temporal lobe; monkey; perception; perirhinal cortex; rat

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