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J Cereb Blood Flow Metab. 1990 Jan;10(1):133-5.

PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus.

Author information

1
Institut für Pharmakologie und Toxikologie, Marburg, F.R.G.

Abstract

We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.

PMID:
2298830
DOI:
10.1038/jcbfm.1990.17
[Indexed for MEDLINE]

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