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J Exp Med. 2012 Sep 24;209(10):1813-23, S1-2. Epub 2012 Sep 17.

Macrophages induce differentiation of plasma cells through CXCL10/IP-10.

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1
Baylor Institute for Immunology Research, Dallas, TX 75204, USA. wei.xu.wx6@roche.com

Abstract

In tonsils, CD138(+) plasma cells (PCs) are surrounded by CD163(+) resident macrophages (Ms). We show here that human Ms (isolated from tonsils or generated from monocytes in vitro) drive activated B cells to differentiate into CD138(+)CD38(++) PCs through secreted CXCL10/IP-10 and VCAM-1 contact. IP-10 production by Ms is induced by B cell-derived IL-6 and depends on STAT3 phosphorylation. Furthermore, IP-10 amplifies the production of IL-6 by B cells, which sustains the STAT3 signals that lead to PC differentiation. IP-10-deficient mice challenged with NP-Ficoll show a decreased frequency of NP-specific PCs and lower titers of antibodies. Thus, our results reveal a novel dialog between Ms and B cells, in which IP-10 acts as a PC differentiation factor.

PMID:
22987802
PMCID:
PMC3457728
DOI:
10.1084/jem.20112142
[Indexed for MEDLINE]
Free PMC Article
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