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Head Neck. 2013 Oct;35(10):1475-81. doi: 10.1002/hed.23169. Epub 2012 Sep 18.

Identification of upregulated genes in oral squamous cell carcinomas.

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  • 1Department of Head and Neck Surgery, A. C. Camargo Cancer Hospital, São Paulo, São Paulo, Brazil; Ludwig Institute for Cancer Research, São Paulo Branch, São Paulo, Brazil.

Abstract

BACKGROUND:

Oral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors.

METHODS:

To identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription-polymerase chain reaction (qRT-PCR) approach to determine the expression level of selected genes in tumor samples.

RESULTS AND CONCLUSIONS:

The ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT-PCR validation and 3 of them (ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy.

Copyright © 2013 Wiley Periodicals, Inc.

KEYWORDS:

head and neck squamous cell carcinoma; quantitative RT-PCR; upregulation

[PubMed - indexed for MEDLINE]
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