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J Magn Reson Imaging. 2013 Jan;37(1):59-66. doi: 10.1002/jmri.23805. Epub 2012 Sep 17.

White matter changes in primary dystonia determined by 2D distribution analysis of diffusion tensor images.

Author information

1
Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.

Abstract

PURPOSE:

To determine brain tissue affected by dystonia by making group comparison of parameter-based diffusion tensor imaging (DTI) distributions of patients with control subjects. A 2D distribution analysis of mean diffusivity and fractional anisotropy index was used for modeling brain tissues according to the inherent diffusion characteristics.

MATERIALS AND METHODS:

Seven affected carriers of the DYT1 dystonia mutation and eight healthy control subjects were imaged for a previous study. We employed a 2D distribution analysis of all the diffusion voxels and a four compartmental brain model for group comparison of the dystonia subjects and controls.

RESULTS:

Our analysis showed disease involvement in the white matter of the patients. Excellent tissue characterization was achieved automatically using the 2D distribution analysis based on a physical brain model.

CONCLUSION:

This 2D analysis implicated white matter in dystonia and could be useful as a screening tool in diseases with unknown pathologies.

PMID:
22987399
PMCID:
PMC4086882
DOI:
10.1002/jmri.23805
[Indexed for MEDLINE]
Free PMC Article
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