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Nat Chem Biol. 2012 Oct;8(10):812-3. doi: 10.1038/nchembio.1066.

GhoSTly bacterial persisters.

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1
Bacterial Genetic and Physiology Laboratory, Université Libre de Bruxelles, Brussels, Belgium. lvmelder@ulb.ac.be

Abstract

Bacterial persisters consist of a phenotypic subpopulation that survives antibiotic treatment, prolonging infection. The GhoT toxin from the newly discovered ghoS-ghoT toxin-antitoxin system contributes to persistence, most likely by interfering with bacterial inner membrane integrity.

PMID:
22987009
DOI:
10.1038/nchembio.1066
[Indexed for MEDLINE]
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