Format

Send to

Choose Destination
See comment in PubMed Commons below
Gynecol Obstet Invest. 2012;74(4):288-97. doi: 10.1159/000341706. Epub 2012 Sep 19.

Endometrial stromal sarcoma arising from endometriosis: a clinicopathological study and literature review.

Author information

1
State Key Laboratory of Oncology in South China, Guangzhou, PR China.

Abstract

OBJECTIVES:

We aimed to investigate the nature of endometrial stromal sarcoma (ESS) arising from endometriosis.

METHODS:

The clinical data of 5 patients with ESS arising from endometriosis were reviewed retrospectively. The expression of CD117, HER2/neu, EGFR, VEGF, and PDGFR was analyzed by immunohistochemical staining.

RESULTS:

The median age of the 5 patients was 45 years. The primary tumor sites were the ovary in 2, the pelvis in 2, and the cervical canal in 1 patient. Three patients had disseminated disease at diagnosis. Four patients underwent complete tumor resection. All of the 5 cases received adjuvant chemotherapy and 2 received progesterone therapy, while none were treated with radiotherapy. No recurrence occurred in the 4 cases who had complete tumor resection, and the only patient who progressed was the patient in whom the tumor was unresectable. Tumor cells in all cases exhibited positive staining for PDGFR and were negative for CD117 and HER2/neu. The expression of EGFR and VEGF was observed in 2 and 4 cases, respectively.

CONCLUSION:

ESS arising from endometriosis is rare. Complete tumor resection in ESS arising from endometriosis may reduce the recurrence rate.

PMID:
22986788
DOI:
10.1159/000341706
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Support Center