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Nat Rev Genet. 2012 Oct;13(10):720-31. doi: 10.1038/nrg3293.

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans.

Author information

1
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. adelmank@niehs.nih.gov

Abstract

Recent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate RNA synthesis, emerging evidence points to the pausing of Pol II during early elongation as a widespread regulatory mechanism in higher eukaryotes. Current data indicate that pausing is particularly enriched at genes in signal-responsive pathways. Here the evidence for pausing of Pol II from recent high-throughput studies will be discussed, as well as the potential interconnected functions of promoter-proximally paused Pol II.

PMID:
22986266
PMCID:
PMC3552498
DOI:
10.1038/nrg3293
[Indexed for MEDLINE]
Free PMC Article
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