Format

Send to

Choose Destination
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:287-93. doi: 10.1016/j.pnpbp.2012.08.020. Epub 2012 Sep 15.

Physiologic complexity and aging: implications for physical function and rehabilitation.

Author information

1
Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. bmanor@bidmc.harvard.edu

Abstract

The dynamics of most healthy physiological processes are complex, in that they are comprised of fluctuations with information-rich structure correlated over multiple temporospatial scales. Lipsitz and Goldberger (1992) first proposed that the aging process may be characterized by a progressive loss of physiologic complexity. We contend that this loss of complexity results in functional decline of the organism by diminishing the range of available, adaptive responses to the innumerable stressors of everyday life. From this relationship, it follows that rehabilitative interventions may be optimized by targeting the complex dynamics of human physiology, and by quantifying their effects using tools derived from complex systems theory. Here, we first discuss several caveats that one must consider when examining the functional and rehabilitative implications of physiologic complexity. We then review available evidence regarding the relationship between physiologic complexity and system functionality, as well as the potential for interventions to restore the complex dynamics that characterize healthy physiological function.

KEYWORDS:

BOLD; Cardiovascular; Complexity; MEG; MRI; MSE; Multiscale entropy; Nonlinear; Postural control; blood-oxygen level dependent; magnetic resonance imaging; magnetoencephalography; multi-scale entropy

PMID:
22985940
PMCID:
PMC3568237
DOI:
10.1016/j.pnpbp.2012.08.020
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center