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Neural Netw. 2013 Nov;47:11-7. doi: 10.1016/j.neunet.2012.08.001. Epub 2012 Sep 5.

Dendritic calcium signaling in cerebellar Purkinje cell.

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Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan. Electronic address:


The Purkinje cells in the cerebellum are unique neurons that generate local and global Ca(2+) signals in response to two types of excitatory inputs, parallel fiber and climbing fiber, respectively. The spatiotemporal distribution and interaction of these synaptic inputs produce complex patterns of Ca(2+) dynamics in the Purkinje cell dendrites. The Ca(2+) signals originate from Ca(2+) influx through voltage-gated Ca(2+) channels and Ca(2+) release from intracellular stores that are mediated by the metabotropic glutamate receptor signaling pathway. These Ca(2+) signals are essential for the induction of various forms of synaptic plasticity and for controlling the input-output relationship of Purkinje cells. In this article we review Ca(2+) signaling in Purkinje cell dendrites.


Ca imaging; Ca spikes; Climbing fiber; Parallel fiber; Patch-clamp recordings; Synapse elimination; Synaptic plasticity

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