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Curr Opin Cell Biol. 2013 Feb;25(1):107-15. doi: 10.1016/j.ceb.2012.08.012. Epub 2012 Sep 15.

Traveling waves in actin dynamics and cell motility.

Author information

1
Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616, USA. jun@math.ucdavis.edu

Abstract

Much of current understanding of cell motility arose from studying steady treadmilling of actin arrays. Recently, there have been a growing number of observations of a more complex, non-steady, actin behavior, including self-organized waves. It is becoming clear that these waves result from activation and inhibition feedbacks in actin dynamics acting on different scales, but the exact molecular nature of these feedbacks and the respective roles of biomechanics and biochemistry are still unclear. Here, we review recent advances achieved in experimental and theoretical studies of actin waves and discuss mechanisms and physiological significance of wavy protrusions.

PMID:
22985541
PMCID:
PMC3542403
DOI:
10.1016/j.ceb.2012.08.012
[Indexed for MEDLINE]
Free PMC Article
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