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Epilepsia. 2012 Nov;53(11):1937-47. doi: 10.1111/j.1528-1167.2012.03662.x. Epub 2012 Sep 17.

Altered θ coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy.

Author information

1
Bernstein Center Freiburg, University of Freiburg, Freiburg, Germany.

Abstract

PURPOSE:

  Temporal lobe epilepsy is often accompanied by neuron loss and rewiring in the hippocampus. We hypothesized that the interaction of subnetworks of the entorhinal-hippocampal loop between epileptic events should show significant signatures of these pathologic changes.

METHODS:

  We combined simultaneous recording of local field potentials in entorhinal cortex (EC) and dentate gyrus (DG) in freely behaving kainate-injected mice with histologic analyses and computational modeling.

KEY FINDINGS:

  In healthy mice, theta band activity was synchronized between EC and DG. In contrast, in epileptic mice, theta activity in the EC was delayed with respect to the DG. A computational neural mass model suggests that hippocampal cell loss imbalances the coupling of subnetworks, introducing the shift.

SIGNIFICANCE:

  We show that pathologic dynamics in epilepsy encompass ongoing activity in the entorhinal-hippocampal loop beyond acute epileptiform activity. This predominantly affects theta band activity, which links this shift in entorhinal-hippocampal interaction to behavioral aspects in epilepsy.

[Indexed for MEDLINE]
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