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Eur Arch Otorhinolaryngol. 2013 May;270(5):1581-92. doi: 10.1007/s00405-012-2170-9. Epub 2012 Sep 15.

Prognostic biological features in neck dissection specimens.

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1
Oral Pathology, School of Dentistry and Dental Hospital, University of Liverpool, Liverpool, UK.

Abstract

The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.

PMID:
22983222
DOI:
10.1007/s00405-012-2170-9
[Indexed for MEDLINE]
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