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Neuropsychologia. 2012 Dec;50(14):3564-72. doi: 10.1016/j.neuropsychologia.2012.09.005. Epub 2012 Sep 11.

Discourse production following injury to the dorsolateral prefrontal cortex.

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Speech, Language, and Hearing Sciences Department, University of Connecticut, 850 Bolton Road, Storrs, CT 06269-1085, USA.


Individuals with damage to the prefrontal cortex, and the dorsolateral prefrontal cortex (DLPFC) in particular, often demonstrate difficulties with the formulation of complex language not attributable to aphasia. The present study employed a discourse analysis procedure to characterize the language of individuals with left (L) or right (R) DLPFC lesions. All participants were 30-35 years post-onset of injury and presented with persistent discourse impairments. The discourse performance of the R DLPFC group was not significantly different from either the L DLPFC group or the non-injured comparison group. Individuals from the L DLPFC group demonstrated specific difficulties with narrative coherence and inclusion of critical story components. Both measures were significantly different from the comparison group. The discourse ability of the DLPFC groups was significantly correlated with measures of working memory. Findings support the use of discourse analysis for examining language impairments in individuals with PFC lesions.

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