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Cell Metab. 2012 Oct 3;16(4):420-34. doi: 10.1016/j.cmet.2012.06.017. Epub 2012 Sep 13.

Sphingolipid signaling in metabolic disorders.

Author information

1
Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. tih2002@med.cornell.edu

Abstract

Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being recognized as critical players in metabolic diseases. This review focuses on recent advances in cellular and physiological mechanisms of sphingolipid regulation and how sphingolipid signaling influences metabolic diseases. Progress in this area may contribute to new understanding and therapeutic options in complex diseases such as atherosclerosis, diabetes, metabolic syndromes, and cancer.

PMID:
22982021
PMCID:
PMC3466368
DOI:
10.1016/j.cmet.2012.06.017
[Indexed for MEDLINE]
Free PMC Article

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