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J Clin Virol. 2012 Dec;55(4):334-8. doi: 10.1016/j.jcv.2012.08.015. Epub 2012 Sep 12.

Analysis of Vis-NIR spectra changes to measure the inflammatory response in the nasal mucosal region of influenza A and B virus-infected patients.

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1
Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. sakudo@med.u-ryukyu.ac.jp

Abstract

BACKGROUND:

Human influenza A and B viruses cause severe seasonal respiratory tract infections, especially in infants and young children. Influenza A and B viruses have been reported to produce different symptoms and/or severity in infected patients, although these remain inconclusive.

OBJECTIVES AND STUDY DESIGN:

In this study, non-invasive visible and near-infrared (Vis-NIR) spectroscopy was used for comparative analysis of the inflammatory response to influenza A and B virus infections, by measuring changes in water peak (970 nm) spectra collected from patient nasal mucosal regions.

RESULTS:

The results suggested that infection with influenza B virus induced more severe inflammatory responses in the nasal mucosal region than influenza A virus.

CONCLUSIONS:

These are the first data showing different inflammatory responses to influenza A and B viruses at the sites of virus infection.

PMID:
22981622
DOI:
10.1016/j.jcv.2012.08.015
[Indexed for MEDLINE]
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