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Cell Rep. 2012 Sep 27;2(3):526-39. doi: 10.1016/j.celrep.2012.08.012. Epub 2012 Sep 13.

Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes.

Author information

1
Molecular Oncology Programme, Spanish National Cancer Centre (CNIO), Madrid 28034, Spain.

Abstract

Cell competition is a mechanism that eliminates slow dividing cells from a growing population. It is believed that the genes wasp, psr, and draper are active in the cells that win the competition ("winner cells") and that they are essential in the winner cells for the induction of apoptosis and for the elimination of the "loser cells." Here, we show that lack of those genes in winner cells appears to be dispensable for cell-competition-induced apoptosis and during dmyc-induced supercompetition. Moreover, winner clones do not need those genes in order to preserve their growth advantage. Finally, we find that most of the clearance of the apoptotic debris is not performed by winners but by recruited hemocytes, which are required for the removal of the apoptotic corpses at the very end. Therefore, engulfment is a consequence-not a cause-of loser cells' death.

PMID:
22981235
DOI:
10.1016/j.celrep.2012.08.012
[Indexed for MEDLINE]
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