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Ophthalmic Epidemiol. 2012 Oct;19(5):285-92. doi: 10.3109/09286586.2011.649228.

Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis.

Author information

1
Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA.

Abstract

PURPOSE:

To evaluate the risk of developing Alzheimer disease (AD) or other dementia in patients diagnosed with open-angle glaucoma (OAG) in a nationally representative longitudinal sample of elderly persons.

METHODS:

This retrospective cohort study (January 1, 1994-December 31, 2007) used Medicare 5% claims data. We identified beneficiaries aged 68+ years who had at least two claims with diagnoses of OAG and no Alzheimer or other dementia in 1994, using a 3-year look-back period between 1991 and 1993 (nā€‰=ā€‰63,235) and beneficiaries matched on age, sex, race, and Charlson index without a diagnosis of OAG throughout the observational period (nā€‰=ā€‰63,235), using propensity score matching. Using a Cox Proportional Hazards model, we analyzed time to AD diagnosis and time to AD or other dementia diagnosis.

RESULTS:

Elderly individuals diagnosed with OAG did not have an increased rate of AD and other dementia diagnosis compared to those without OAG during a 14-year follow-up period, even after controlling for relevant covariates present at baseline.

CONCLUSIONS:

Individuals aged 68+ years diagnosed with OAG have a decreased rate of AD or other dementia diagnosis compared to control patients without an OAG diagnosis. Although OAG and AD are both age-related neurodegenerative diseases, our findings do not support a positive association.

PMID:
22978529
PMCID:
PMC3523354
DOI:
10.3109/09286586.2011.649228
[Indexed for MEDLINE]
Free PMC Article

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