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Nat Prod Commun. 2012 Aug;7(8):977-8.

The cytotoxic activity of diterpenoids from Isodon species.

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Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2-3-10, Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.


Fifteen Isodon diterpenoids (1-15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells. Kamebanin (14) showed efficient cytotoxic activity against HeLa and HL-60 cells. In addition, although dihydroenmein (2) and trichorabdal B (7) were inactive against several tested cell types, they were found to have cytotoxic-enhancing activity of VCR against VCR-resistant P388 cells.

[Indexed for MEDLINE]

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