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Lab Chip. 2012 Nov 7;12(21):4465-71. doi: 10.1039/c2lc40392g.

A magnetic cell-based sensor.

Author information

1
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

Cell-based sensing represents a new paradigm for performing direct and accurate detection of cell- or tissue-specific responses by incorporating living cells or tissues as an integral part of a sensor. Here we report a new magnetic cell-based sensing platform by combining magnetic sensors implemented in the complementary metal-oxide-semiconductor (CMOS) integrated microelectronics process with cardiac progenitor cells that are differentiated directly on-chip. We show that the pulsatile movements of on-chip cardiac progenitor cells can be monitored in a real-time manner. Our work provides a new low-cost approach to enable high-throughput screening systems as used in drug development and hand-held devices for point-of-care (PoC) biomedical diagnostic applications.

PMID:
22976747
DOI:
10.1039/c2lc40392g
[Indexed for MEDLINE]

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