Send to

Choose Destination
J Alzheimers Dis. 2013;33(2):323-8. doi: 10.3233/JAD-2012-120874.

Inflammatory proteins and the severity of dilated Virchow-Robin Spaces in the elderly.

Author information

INSERM U708 Neuroepidemiology, Bordeaux, France.


Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for IOS Press
Loading ...
Support Center