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J Alzheimers Dis. 2013;33(2):323-8. doi: 10.3233/JAD-2012-120874.

Inflammatory proteins and the severity of dilated Virchow-Robin Spaces in the elderly.

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1
INSERM U708 Neuroepidemiology, Bordeaux, France.

Abstract

Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.

PMID:
22976070
DOI:
10.3233/JAD-2012-120874
[Indexed for MEDLINE]

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